What is mesothelioma?

Mesothelioma is a rare type of cancer that starts in mesothelial cells, which make up the lining around certain body parts. Also known as malignant mesothelioma, this cancer usually occurs in people exposed to asbestos, but symptoms may not develop until 10-50 years later.

The most common type of mesothelioma is pleural mesothelioma, which affects the tissue in the lining of the lungs. But the cancer can develop in other areas of the body, too. There are only about 3,000 cases of mesothelioma diagnosed each year in the United States.

Types of mesothelioma

There are four main types of mesothelioma—based on where in the body the cancer first starts to form. Pleural mesothelioma makes up more than 80% of all mesothelioma cases. Mesothelioma can also develop in the peritoneum (lining of the abdomen), pericardium (the lining of the heart) or the lining of the testicles.

What are mesothelioma symptoms?

Mesothelioma symptoms can vary depending on where in the body the cancer starts to grow, and it may take a long time for symptoms to appear after asbestos exposure. At first, your symptoms may be similar to other common conditions, like flu or pneumonia. One common symptom of mesothelioma is pleural effusion, fluid buildup in the pleural lining of the chest. You may also have symptoms that affect the whole body, such as fatigue.

Common mesothelioma symptoms

As mesothelioma starts to grow, it can affect nearby organs, causing many different symptoms:

  • Shortness of breath or trouble breathing
  • Fluid around the lungs, abdomen, heart or testicles
  • Chest, back, rib, abdomen or testicular pain
  • Dry cough and hoarseness
  • Loss of appetite and weight loss
  • Fatigue
  • Digestive problems
  • Swelling in the face, arms or legs
  • Irregular heartbeat or palpitations

Learn more about mesothelioma symptoms

When to see a doctor

Mesothelioma causes

Mesothelioma occurs when abnormal cells in the lining of the lungs, heart, abdomen or testes start to grow rapidly. We don’t fully understand why this happens with mesothelioma, but doctors know some factors that may put you more at risk.

The majority of mesothelioma cases—about 80% —are linked to asbestos exposure. But other factors like your environment, health history, lifestyle or genetics could also play a role in causing mesothelioma.

Mesothelioma risk factors

Knowing your risk of mesothelioma and its symptoms means that you and your healthcare team can be proactive in detecting any signs of the disease. While some risk factors may be out of your control, there are steps you can take to protect yourself.

How is mesothelioma diagnosed?

If you’re having any symptoms of mesothelioma, especially if you’ve been exposed to asbestos, your doctor has several tools to help diagnose your condition. You’ll likely have imaging or blood tests to give your team more information. A biopsy will take tissue samples to diagnose mesothelioma.

If mesothelioma is found through your biopsy, your care team will also classify your condition based on the specific type of cells involved. The most common cell type in mesothelioma is epithelioid cells—found in about 70% of cases. Another less common type is sarcomatoid cells. If you have both types of cells, it’s called biphasic mesothelioma.

Medical history and physical exam

Your care starts with a visit to the doctor, where you'll discuss your medical history and any risk factors for mesothelioma, such as asbestos exposure. During your exam, your doctor will listen to your heart and lungs, tap your abdomen or chest and look for signs of fluid buildup.

If you have symptoms of pleural mesothelioma, you may also have a pulmonary function test to check how your lungs are working. As mesothelioma shares symptoms with many other conditions, your doctor may order additional tests after your exam to help with diagnosis.

Mesothelioma stages

When you're diagnosed with mesothelioma, your care team will place your cancer into one of four stages. Your cancer stage is important in your mesothelioma care because it helps you and your team make informed choices about the right treatment options for you. Stages 1 and 2 are considered early-stage cancer. Stages 3 and 4 are more advanced.

Treatment for mesothelioma

When it comes to treatment for mesothelioma, this rare type of cancer requires a specialized, team approach. You may visit multiple doctors who will work together to create a plan for your needs and specific stage of cancer.

Surgery is a standard treatment option in the earlier stages of mesothelioma. Your treatment could also include chemotherapy, radiation therapy, immunotherapy, targeted therapies, pain management or palliative care. Often, you’ll have a combination of treatments.

Surgery

Surgery can be used to treat mesothelioma to remove as much of the cancer as possible. Though often, mesothelioma can’t be completely removed with surgery. The type of surgery that your care team recommends will depend on the location of your cancer and how much your mesothelioma has spread.

  • Extrapleural pneumonectomy: This extensive and complex surgery aims to remove all the areas of cancer caused by pleural mesothelioma, like a pneumonectomy, where your surgeon will remove one of your lungs. An extrapleural pneumonectomy also removes the lining in the chest on that same side, part of your diaphragm, lymph nodes and, in some cases, the sac around your heart.
  • Pleurectomy and decortication: During this surgery, known as P/D, your doctor removes the lining around the affected lung and the pleural coating around your lung and diaphragm on that side of the body.
  • Debulking: Debulking surgery removes as many areas of cancer as possible in the lining of the lungs or abdomen, while leaving as much healthy tissue in place as possible. When used in the lining of the lungs, it may be called a partial pleurectomy.
  • Pleurodesis: Pleurodesis is a procedure that removes fluid buildup and then uses chemicals to make scar tissue in the lining of the lungs. This process prevents any additional fluid from building up in the space.

Finding specialized mesothelioma cancer treatment

Baylor Scott & White Center for Thoracic Surgery - Dallas

3410 Worth St Ste 760, Dallas, TX, 75246

Not accepting walk-ins

Not accepting walk-ins

Baylor Scott & White Center for Thoracic Surgery - Rockwall

6701 Heritage Pkwy Ste 130, Rockwall, TX, 75087

Not accepting walk-ins

Not accepting walk-ins

Baylor Scott & White Center for Thoracic Surgery - Waxahachie

2480 N Interstate 35E , Waxahachie, TX, 75165

Not accepting walk-ins

Not accepting walk-ins

Baylor Scott & White Charles A. Sammons Cancer Center - Irving

2001 N MacArthur Blvd Ste 120, Irving, TX, 75061

Not accepting walk-ins

Baylor Scott & White Charles A. Sammons Cancer Center - Waxahachie

2380 N Interstate 35E , Waxahachie, TX, 75165

Not accepting walk-ins

Baylor Scott & White Imaging Center - Forney

763 E US Hwy 80 Ste 120, Forney, TX, 75126

Not accepting walk-ins

Baylor Scott & White Imaging Center - Greenville

4400 Interstate 30 W Ste 200, Greenville, TX, 75402

Not accepting walk-ins

Baylor Scott & White Imaging Center - Rockwall

1005 W Ralph Hall Pkwy Ste 121, Rockwall, TX, 75032

Not accepting walk-ins

Baylor Scott & White Imaging Center - Wylie

2300 W FM 544 Ste 110, Wylie, TX, 75098

Not accepting walk-ins

Baylor Scott & White Medical Center - Austin

5245 W US Hwy 290 Service Rd , Austin, TX, 78735

Accepting walk-ins

Baylor Scott & White Medical Center - Buda

5330 Overpass Rd , Buda, TX, 78610

Accepting walk-ins

Baylor Scott & White Medical Center - College Station

700 Scott and White Dr , College Station, TX, 77845

Accepting walk-ins

Baylor Scott & White Medical Center - Lakeway

100 Medical Pkwy , Lakeway, TX, 78738

Accepting walk-ins

Baylor Scott & White Medical Center - Pflugerville (Building 1)

2600 E Pflugerville Pkwy Bldg 1, Ste 100, Pflugerville, TX, 78660

Accepting walk-ins

Baylor Scott & White Medical Center - Round Rock

300 University Blvd , Round Rock, TX, 78665

Accepting walk-ins

Baylor Scott & White Medical Center - Taylor

305 Mallard Ln , Taylor, TX, 76574

Accepting walk-ins

Baylor Scott & White Medical Center - Temple

2401 S 31st St , Temple, TX, 76508

Accepting walk-ins

Baylor Scott & White Medical Plaza 900 - College Station

900 Scott and White Dr , College Station, TX, 77845

Not accepting walk-ins

Baylor Scott & White Pulmonary and Sleep Medicine Clinic - Waco

120 Hillcrest Medical Blvd Bldg II, Ste 305, Waco, TX, 76712

Not accepting walk-ins

Not accepting walk-ins

Frequently asked questions